Abstract
A new, macroporous, synthetic polymer, Hydrophase TM HP-PEI, having highly hydrophilic surface characteristics enhanced by evenly distributed polyethyleneimine groups on its surface, was evaluated as an high-performance ion-exchange chromatographic packing material for the separation of proteins and nucleotides. A steel column (100 mm × 7.8 mm I.D.) packed with this material produces more than 33 000 plates per m. This base polymer included large proteins, such as thyroglobulin and apoferritin, in a size-exclusion mode. With various proteins it gave high recovery, high resolution and high capacity.
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