Abstract
In smooth muscle, Ca 2+ regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca 2+ concentration ([Ca 2+] c) in smooth muscle by permitting Ca 2+ entry across the plasma membrane and release of the ion from intracellular Ca 2+ stores. The control of [Ca 2+] c relies on feedback modulation of the entry and release channels by Ca 2+ itself. Local rises in [Ca 2+] c may promote or inhibit channel activity directly or indirectly. The latter may arise from Ca 2+ regulation of ionic conductances in the plasma membrane to provide control of cell excitability and so [Ca 2+] c entry. Organelles such as mitochondria may also contribute significantly to the feedback regulation of ion channel activity by the control of Ca 2+ or redox status of the cell. This brief review describes the feedback regulation of Ca 2+ release from the internal Ca 2+ store and of plasma membrane excitability in smooth muscle.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
