Abstract
Ion Channel Modulation in Spinal/Trigeminal Synaptic Plasticity
Highlights
dorsal horn (DH) neurons are mechanical touch, pinch, thermal heat, and cold
The paper proceeds to discuss recent published work regarding the contributions in spinal DH of ionotropic glutamate receptors and voltage-gated Ca2+ channels (VGCCs) to both long-term potentiation (LTP), an increase in the strength of synaptic transmission, and/or pain hypersensitivity
Park et al “Dual effect of exogenous nitric oxide on neuronal excitability in rat substantia gelatinosa neurons” report a remarkable effect of nitric oxide on the excitability of substantia gelatinosa (SG) neurons located in lamina II of the spinal DH
Summary
The first paper “Ionotropic glutamate receptors and voltage-gated Ca2+ channels in long-term potentiation of spinal dorsal horn synapses and pain hypersensitivity” in this issue introduces the anatomical and synaptic organization of the spinal DH. In this issue’s first paper, the authors synthesize findings in the recent literature to present an integrated model of the synaptic organization that supports pain processing in the spinal DH.
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