Abstract
In 1948 Barrett, Goodman, and Dittmer synthesized several organic combinations of halogens with thio uracil, of which 5-iodo-2-thiouracil proved most suitable for clinical trial. Because of the avidity of the hyper thyroid gland for iodine, the concentration of thiouracil in the gland might be expected to be greater after administration of iodothiouracil than after an equiva lent dose of uniodinated thiouracil ; a lower dosage could then be used, and the frequency of toxic effects would thus be reduced. It was also thought that the concurrent administration of iodine might diminish the hyperplasia and vascularity of the thyroid gland otherwise induced by the thiouracil ; a reduction in the duration of pre-operative treatment would thus be possible and the technical difficulties of excision would be minimized.
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