Abstract
With the aid of a specific GC-MS method utilizing negative ion-chemical ionization, the extracellular and intracellular concentrations of the free 2-thiouracils, 2-thiouracil and 6-propyl-2-thiouracil were measured after their incubation with melanotic and amelanotic melanocytes. Only with the melanotic cell preparation exposed to low concentrations of thiouracil (40 ng/106 cells) was there a reduction of the thiouracil concentration. When the extracellular 2-thiouracil concentration was increased a thousandfold (40 μg/106 cells), appreciable accumulation by the melanotic melanocytes was observed only with the more lipophilic 2-thiouracil, propylthiouracil, which also paralleled its greater toxicity compared with thiouracil. Both these observations suggest increased propylthiouracil cell penetration compared with thiouracil due to its greater lipophilicity.
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