Abstract
Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids, N-11-( p-iodophenylsulfonamide)-undecanoic acid and N-12-( p-iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented.
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