Abstract
The nitric oxide (NO) has important participation in the control of hypothalamic–pituitary axis. The authors investigated the effect of NO donor, isosorbide dinitrate (ISDN), on prolactin (PRL) release induced by immobilization stress (IS) in male rats. Pretreatment with the NO donor, ISDN (2.5; 5 and 10 mg/kg), inhibited about 60–85% of the PRL response to IS. It is concluded that NO does participate in the regulation of PRL response to IS.
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