Abstract
1. 1. Central serotoninergic participation in prolactin (PRL) secretion regulation is a well-established event Furthermore, S-HT may participate in the mediation of stress-induced PRL release. 2. 2. The authors investigated the effect of the blockade of 5-HT 3 receptors on the PRL release induced by immobilization stress in male rats. 3. 3. Pretreatment with the 5-HT 3 receptor antagonist, ondansetron (0.10 – 1.0 mg/kg i.p.), inhibited about 50% of the PRL response to immobilization stress. A lower dose of ondansetron (0.05 mg/kg i.p.) had no effect on the PRL response. No dose-response inhibition was observed. 4. 4. It is concluded that serotoninergic activation related to the mediation of the stress-induced PRL response involves the 5-HT 3 receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Progress in Neuropsychopharmacology & Biological Psychiatry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
