Abstract
Abstract Mouse formylpeptide receptor 2 (mFPR2) is a homologue of the human G-protein coupled chemoattractant receptor FPR2 (FPRL1), which interacts with many pathogen and host-derived agonists. Our previous study revealed reduced allergic airway inflammatory and immune responses in mFPR2 deficient (mFPR2-/-) mice in association with diminished dendritic cell (DC) recruitment into the airway and draining lymph nodes. These defects prompted us to investigate the maturation and function of DCs in mFPR2-/- mice. We found that DC maturation, trafficking and induction of T-cell proliferation are impaired in mFPR2-/- mice. In addition, DCs from mFPR2-/- mice exhibited diminished signaling of p38 MAPK and NF-κB triggered by maturation stimulants. Our observations indicate a non-redundant role for mFPR2 in DC maturation and function in immune responses.
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