Abstract
The present study investigated the involvement of the serotonin (5-hydroxytryptamine, 5-HT) neuronal system in the Δ 9-tetrahydrocannabinol-induced impairment of spatial memory in the eight-arm radial maze in rats. Δ 9-Tetrahydrocannabinol (6 mg/kg, i.p.), which impairs spatial memory, significantly increased the 5-HT content in the ventral hippocampus. A microdialysis study showed that Δ 9-tetrahydrocannabinol (6 mg/kg, i.p.) decreased 5-HT release in the ventral hippocampus. The 5-HT precursor, 5-hydroxy- l-tryptophan (5-HTP; 50 mg/kg, i.p.), the 5-HT re-uptake inhibitor, clomipramine (0.01 and 0.1 mg/kg, i.p.), the 5-HT receptor agonist, 5-methoxy- N, N-dimethyltryptamine (5-MeODMT; 0.01 and 0.03 mg/kg, i.p.), and the 5-HT 2 receptor agonist, 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (DOI; 10 μg/kg, i.p.), significantly attenuated the Δ 9-tetrahydrocannabinol-induced impairment of spatial memory. These results suggest that the 5-HT neuronal system may be involved in the Δ 9-tetrahydrocannabinol-induced impairment of spatial memory.
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