Abstract
The purpose of this study was to identify brain sites that contribute to the Δ 9-tetrahydrocannabinol (Δ 9-THC)-induced impairment of spatial memory in rats. Rats were tested in the eight-arm radial maze after microinjections of Δ 9-THC into one of 14 different brain regions. The bilateral microinjection of Δ 9-THC (20 μg/side) impaired spatial memory when injected into the dorsal hippocampus (DH), ventral hippocampus (VH) or dorsomedial thalamus nucleus (DMT). However, rats treated with Δ 9-THC into DMT produced perseverative behavior which has not been observed by systemic administration of Δ 9-THC. On the other hand, spatial memory was unaffected by microinjections of Δ 9-THC into the other 11 areas examined: frontal (FC) and frontoparietal (FPC) cortex, central (ACE) and basolateral (ABL) amygdaloid nucleus, medial caudate putamen (CPM), lateral hypothalamus (LH), mammillary body (MB), basal forebrain (BF), medial septal nucleus (SEP) and dorsal (DR) and median (MR) raphe nucleus. These results suggest that DH and VH may be important brain sites for the Δ 9-THC-induced impairment of spatial memory.
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