In-vivo Assessment of Tranquilizer Activity of Various Extracts of Cajanus cajan Leaves in Mice

Abstract

Background: Cajanus cajan is a legume of the plant family Fabaceae. Another name of this plant is the red gram, gungo pea, and no-eye pea. It is a multifaceted plant as it is widely often consumed as a dal. It contains wealthy proteins. The whole plant parts are utilized for silkworms as a vegetable; tops, green leaf, and husk are utilized as feed. Objective: The objective of the analysis was to determine the anti-anxiety effect of varied extracts viz n-hexane, chloroform, ethyl acetate, and methanol of the leaves of Cajanus cajan with an EPM (Elevated plus maze) as well as actophotometer model in albino mice. Methods: In the present research, the anti-anxiety activities of several extracts were evaluated viz n-hexane, chloroform, ethyl acetate, & methanol of the leaves of Cajanus cajan with an EPM model in albino mice. Albino mice have ministered with varied extract dosages orally (for example, 200 & 400 mg/kg) and behaviour on the EPM has been seen. The standard usage of Diazepam (2 mg/kg P.O.) (positive control). Results: Results indicate that the methanolic extract of C. cajan manifested a significant as well as maximum dose-dependent impact at 200 & 400 mg/kg on mice with the help of the EPM model and the results were exactly like diazepam (2 mg/kg), the standard antianxiety substance. The model actophotometer exhibited a dose-dependent reduction in locomotor activity compared to control animals, which is shown at two distinct dosages (200 & 400 mg/kg) of Cajanus cajan. Conclusion: The content of polyphenols was shown in the phytochemical test for methanol extract, which could be liable for the anxiolytic potential of Cajanus cajan. This plant might thus also be cultivated as a potentially beneficial anti-anxiety substance.