Abstract
Objective: The objective of this study was designed to gauge the antianxiety activity of varied extracts, namely, n-hexane, chloroform, ethyl acetate, and methanol of the flowers of Tamarindus indica using elevated plus maze (EPM) model in albino mice.
 Methods: Coarsely powdered tamarind was powdered and subjected to exhaustive Soxhlet extraction using n-hexane, chloroform, ethyl acetate, and methanol. Solvents were recovered from all extracts using a rotary vacuum evaporator under reduced pressure. Albino mice have ministered orally with different doses of the extracts (i.e., 200 and 400 mg/kg) and behavior was observed on the EPM. The standard (positive control) employed in the study Diazepam (2 mg/kg, P.O).
 Results: Results indicate that the methanol extract of T. indica flowers showed maximum and significant dose-dependent effect at 200 and 400 mg/kg on EPM, the results were just like the standard antianxiety agent diazepam (2 mg/kg). Locomotor activity evaluated with two different doses of T. indica (200 and 400 mg/kg) using actophotometer. The results were shown to be decreased in a dose dependent model compared to control.
 Conclusion: The methanol extract shows that the presence of polyphenols could be liable for the anxiolytic potential of T. indica. Hence, this plant could also be used as a useful antianxiety agent.
Highlights
Anxiety is a natural human state where in every body experience in their life
The mental disorders occurrence is increasing, and many severe adverse effects, addiction liabilities have been associated with long-term use of prescribed synthetic drugs. This paved the attention of researchers toward natural antianxiety sources
Benzodiazepines, being a big category of agents used for hysteria [2], present a lean margin of safety between the anxiolytic effect and unwanted side effects, which has prompted researchers to gauge new compounds, especially plant-based drugs having less undesirable effects [3]
Summary
Anxiety is a natural human state where in every body experience in their life. Anxiety is the foremost common psychological state problem within the world and it increases rapidly [1]. The mental disorders occurrence is increasing, and many severe adverse effects, addiction liabilities have been associated with long-term use of prescribed synthetic drugs. This paved the attention of researchers toward natural antianxiety sources. It can prompt us to confront to handle difficult challenges that cause us to become psychologically disturbed and, unhealthy, produce anxious disorders such as panic attacks, phobias, and obsessional behaviors. Benzodiazepines, being a big category of agents used for hysteria [2], present a lean margin of safety between the anxiolytic effect and unwanted side effects, which has prompted researchers to gauge new compounds, especially plant-based drugs having less undesirable effects [3]
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