In-vivo anticancer activity of biosynthetic silver nanoparticles of Cassia marginata Roxb against NMU-Induced mammary carcinoma

Abstract

The use of silver nanoparticles in the diagnosis and treatment of cancer is on the rise, and they are becoming more commonly recognized as effective therapeutic agents. Silver nanoparticles of Cassia marginata Roxb were prepared to investigate its anticancer potential in female Sprague-Dawley rats against N-nitroso N-methyl urea-induced mammary carcinoma. In this study, thirty animals were divided into five groups of six each: normal, disease control, Cassia marginata silver nanoparticles at 200 mg/kg, 400 mg/kg, and tamoxifen 10 mg/kg. N-nitroso N-methyl urea (50 mg/kg, i.p) was given twice at 52 days of age and four weeks after the prior treatment in 0.9 % NaCl. A total of two oral doses of Cassia marginata silver nanoparticles were administered, and the results were compared to the results of a single dose of tamoxifen (10 mg/kg, p.o). The tumor incidence rate, average tumor burden, and the total number of tumors were reduced in the treatment groups when compared with the disease control and the silver nanoparticles of Cassia marginata may prevent mammary carcinoma in Sprague-Dawley rats when exposed to N-nitroso N-methyl urea.