Abstract
Matrix tablets of Lovastatin were fabricated using Ae (okra) gum and guar gum, alone or on combination with other excipients. The tablets were evaluated for physical characteristics like hardness, weight variation, friability, swelling index and drug content. In this study Ae(okra ) gum was extracted and purified by the researcher. In vitro release of drug was performed in 0.1NHCl (pH 1.2) (without enzymes) for up to 2 h and the rest of dissolution in citric acid-phosphate buffer (pH 6.0) and phosphate buffer (pH 7.4) up to 3 h. All the physical characteristics of the fabricated tablets were within accepted limit. The tablets with Ae gum gave better release properties. The level of matrix affects drug release. The Ae gum showed better sustained release properties compared to guar gum. Okra gum also served as colon targeted matrix forming material in tablet form using Lovastatin as model drug. Chemical compounds studied In this article: Lovastatin [PubChem CID: 53232]
Published Version
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