Abstract
Rapid detection of infectious pathogens is vital for preventing costless outbreaks and improving human health. Current detection methods oftentimes lack the means to detect infectious pathogens in a simple, rapid, and reliable manner at the time and point of need. Functional nucleic acids (FNAs) – specifically DNA aptamers and DNAzymes – have the potential to overcome these limitations by acting as key components for point-of-care (POC) biosensors due to their distinctive advantages that include high binding affinities and specificities, excellent chemical stability, ease of synthesis and modification, and compatibility with a variety of signal-amplification and signal-transduction mechanisms. In this presentation, I will discuss the work completed in my laboratory, in collaboration with several other groups at McMaster, towards developing simple-to-use analytical devices with integrated FNAs to detect bacterial and viral pathogens, such as E. coli, Salmonella, SARS-CoV-2, porcine epidemic diarrhea virus (PEDV), directly in water, food or clinical samples.
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