Abstract
A tripod-C60 molecule was synthesized and attached onto a Au-coated AFM tip. Using the tripod skeleton of the molecule, tripod-C60 was immobilized onto the Au surface in a dispersed and stable manner, as observed by XPS and AFM imaging. Using an AFM tip functionalized with the tripod-C60, waffle-type DNA origami was scanned under visible light irradiation. Upon scanning, DNA damage was clearly observed by AFM imaging at the single molecule level. Control experiments in the absence of C60 (tripod only), in the dark, or in the presence of L-histidine or D2O confirmed that the observed DNA damage was induced by singlet oxygen (1O2) generated from C60 under photoirradiation.
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