Abstract
The detection of biomarkers and drugs in live cells and animals would allow for more effective studies of the dynamics of cancer and treatment. Toward these ends, single-walled carbon nanotube photoluminescence is suitable for measurements in live cells and in vivo, and nanotube near-infrared emission exhibits sensitivity to the local environment via solvatochromic responses. We developed new optical instrumentation to image carbon nanotubes and to measure spectral changes of carbon nanotube photoluminescence in live cells and animals. Concomitantly, we developed new methods to exacerbate the nanotube emission response to produce large spectral shifts (> 14 nm) upon the binding of cancer biomarkers and chemotherapeutic drugs. The ability to improve measurements and control of carbon nanotube solvatochromism may improve sensitivity and selectivity of nanosensors and potentially expand the application of nanotube-based optical measurements to new classes of bioanalytes.
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