Abstract

Herein, we report the synthesis of polyfunctional BODIPY building blocks suitable to be subjected to several reaction sequences with complete chemoselectivity, which allowed the preparation of complex BODIPY derivatives in a versatile and programmable manner. The reactions included: the Liebeskind-Srogl cross-coupling reaction (LSCC), SNAr, Suzuki, Sonogashira, and Stille couplings and a desufitative reduction of the MeS- group. This novel synthetic protocol is a powerful route to design a library of compounds with tailored photophysical properties for advanced applications. In this context, it is noteworthy the straightforward and cost-less strategies to shift the BODIPY emission deep into the near infrared spectral region but retaining high fluorescence quantum yields.

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