Abstract
30Nov 2016 INVESTIGATIONS SYNTHESIS, CHARACTERIZATION AND EVALUATION OF THE ANTICACANCER ACTIVITY OF NOVEL 2-AMINOPHENYLTHIAZOLE DERIVED HETEROCYCLES. Aisha Y. Hassan , Moshira A. El-Deeb , Marwa T. Sarg and Maha A. Abou-Sharabia. Organic Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Cairo. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls) Al-Azhar University, Cairo.
Highlights
The newly synthesized compounds were evaluated for their in vitro anticancer activity against human Liver cancer HepG2 and Breast cancer MCF7 cell lines compared to the reference drug Doxorubicin
Compounds 3, 7, 15, 17, 18 and 22 exerted highly potent anticancer activity against MCF7 cell line with IC50 values ranging from 4.95-10.8 μg/mL
2-Amino-4-phenylthiazole derivative1a was prepared according to the reported procedure [13] which was further utilized as a building block to synthesize various phenylthiazole derivatives substituted either at the thiazole amino function or fused to the thiazole back bone.treatment of compound 1awith phenylisothiocyanate furnished the corresponding thiourea derivative 2 that was further cyclized to its aminothiazoleanalogue 3
Summary
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls) Al-Azhar University, Cairo
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