Abstract
AbstractIn vitro methods were used to determine the effects of petroleum ether extract of Croton penduliflorus seed oil (PEE-CP) on the guinea pig ileum and rat uterus. Increasing the dose of PEE-CP produced increasing contractile responses in both the guinea pig ileum and rat uterus. Atropine and adrenaline blocked the action of PEE-CP in a dose-dependent manner. Mepyra-mine and hexamethonium partially blocked the responses of the guinea pig ileum and rat uterus to PEE-CP. Some contractions induced by PEE-CP in the guinea pig ileum, which survived te-trodotoxin treatment, were enhanced by neostigmine. PEE-CP appears to produce its effect through cholinergic, histaminergic and β-adrenergic mechanisms.
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