Investigations of the possible pharmacological effects of organotin(II) complexes

Abstract

Antitumour, antifertility and histopathological investigations were carried out on male rats by the use of organotin complexes. The organotin complexes were synthesized by the alkylation of [Sn(TAML n )Cl 2] ( n = 1–4 and TAML n represents the tetraazamacrocyclic ligands) in the presence of CH 3I or C 2H 5Br. The structures of all the complexes have been established on the basis of elemental analyses, conductivity measurements, IR, 1H NMR, 13C NMR, 119Sn NMR and X-ray spectral data. The antitumour effect of the compounds was examined on swiss mice. The results obtained clearly indicated that the compounds, [C 2H 5Sn(TAML 3)C 5H 5N] and [C 2H 5Sn(TAML 4)C 5H 5N] display effective antitumour activity. The emphasis has been given on in vivo study on male albino rats ( Rattus norvegicus) by performing serum analyses, blood analyses and fertility test.