Abstract
This investigation was intended to aid in the selection of impeller design and operating conditions, which would exhibit minimum turbulence in an internal loop reactor for axial flow velocities up to 18 cm/s. For this purpose we measured power consumption, liquid flow velocity and mixing time with two marine propellers (pitch ratio tan alpha =1 and 0.57, respectively) and with flat-blade fan-type impellers (blade angles 10 to 90°). The present results showed that at flow velocities between 7 and 14 cm/s a reduction in the pitch ratio (tan alpha) of the marine propeller from 1 to 0.57 increased the mechanical flow efficiency. In addition, the fan-type impeller with a blade angle of 20° displayed flow characteristics comparable to the marine propellers; therefore, owing to its simple design, the fan-type impeller offers a practical substitute for the marine propellers. In cell culture, draft-tubes used in impeller-driven reactors (internal loop reactors) offer two important features: 1. They simplify the de...
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