Abstract
Emerged coronavirus disease 2019 (COVID-19) was a pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Disease severity is associated with elevated levels of proinflammatory cytokines, such as interleukin-6 (IL-6). Genetic polymorphisms in the regulatory regions of cytokine genes may be associated with differential cytokine production in COVID-19 patients. This study aimed to investigate the association between potentially functional single-nucleotide polymorphisms (SNP) in the promoter region of IL-6 and the severity of susceptibility to COVID-19 in an Iraq population. In total, 120 individuals (40 patients with severe COVID-19, 40 patients with mild COVID-19 and 40 healthy people) were recruited for this cohort study. Genomic DNA was extracted from peripheral blood leukocytes of patients to determine the genotype of SNPrs1800795 (-174 G>C) in the promoter region of the IL-6 gene by Sanger sequencing using ABI3730XL, automated DNA sequencer, by Macrogen Corporation – Korea after sent PCR products.
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