INVESTIGATION ON CLINICAL, SUBCLINICAL CHARACTERISTICS, AND RESULTS OF PEPTIC ULCER TREATMENT IN CHILDREN 

Abstract

Background: Helicobacter pylori is considered the main cause of peptic ulcer in children. Studies show that the current treatment regimens for stomach ulcers caused by HP face many difficulties: partly due to poor adherence to treatment in children and partly due to increasing antibiotic resistance of HP bacteria today. 50% of children and young adults with peptic ulcer disease have multiple recurrences per year and 70% relapse the following year. Understanding the clinical and subclinical characteristics as well as the treatment results for children with peptic ulcer disease caused by HP based on the current treatment regimen will provide doctors with a basis to propose more effective treatment measures for patients. Objectives: To describe the clinical and subclinical characteristics and to investigate factors related to the treatment outcome of peptic ulcer disease caused by Helicobacter pylori in children. Subjects and methods: The study subjects included 61 patients with peptic ulcer disease caused by Helicobacter pylori. Longitudinal follow-up descriptive research method was used. Diagnosis of peptic ulcer disease caused by Helicobacter was performed via gastroduodenal endoscopy and Clotest (+). The patients were treated according to the protocol of the Ministry of Health and were evaluated for improvement in clinical symptoms after 4 weeksBackground: Helicobacter pylori is considered the main cause of peptic ulcer in children. Studies show that the current treatment regimens for stomach ulcers caused by HP face many difficulties: partly due to poor adherence to treatment in children and partly due to increasing antibiotic resistance of HP bacteria today. 50% of children and young adults with peptic ulcer disease have multiple recurrences per year and 70% relapse the following year. Understanding the clinical and subclinical characteristics as well as the treatment results for children with peptic ulcer disease caused by HP based on the current treatment regimen will provide doctors with a basis to propose more effective treatment measures for patients. Objectives: To describe the clinical and subclinical characteristics and to investigate factors related to the treatment outcome of peptic ulcer disease caused by Helicobacter pylori in children. Subjects and methods: The study subjects included 61 patients with peptic ulcer disease caused by Helicobacter pylori. Longitudinal follow-up descriptive research method was used. Diagnosis of peptic ulcer disease caused by Helicobacter was performed via gastroduodenal endoscopy and Clotest (+). The patients were treated according to the protocol of the Ministry of Health and were evaluated for improvement in clinical symptoms after 4 weeks Key words: Peptic ulcer, children, Helicobacter pylori.