Investigation of white matter functional networks in young smokers

Abstract

AimsThis study investigated the changes in the organizational and intrinsical activities of the white matter functional networks (WMFNs) in young smokers using resting-state functional magnetic resonance imaging. MethodsA data-driven approach was used to characterize the WMFNs of 30 young smokers and 30 non-smokers. We applied K-means clustering to the neuroimaging data to delineate the WMFNs. Functional neural activities of the WMFNs were compared between the two groups. Correlation analyses were also conducted for the WMFNs neural activities of and clinical indicators of smoking. ResultsEight WMFNs were identified in both groups. Compared to non-smokers, young smokers demonstrated a different dorsal attention network and lack of a frontostriatal network. The neural activities in the frontal network, deep frontoparietal network, and visual network were reduced in young smokers. Further correlation analyses showed that the decreased neural activity in the deep frontal network and deep frontoparietal network were significantly negatively correlated with the Fagerström Test for Nicotine Dependence. ConclusionYoung smokers exhibited differences in the organizational structure and neural activity intensities of the WMFNs. The present findings may indicate the importance of WMFNs in young smokers, which can help in obtaining a comprehensive understanding of the neural mechanisms underlying smoking addiction.