Investigation of the Therapeutic Effects of Hot Springs Waters Sourced from Afyonkarahisar Region on Experimentally-induced Myocardial infarctus in Rats

Abstract

Myocardial infarction is an important public health problem in human and animals. In this study, myocardial infarction was induced by intraperitoneally injected isoproterenol hydrochloride in saline solution at a dose of 85 mg/kg body weight for 2 days. After myocardial infarction formation, three animals were exed to collect blood and histopathological specimens. The remaining 32 rats were divided into control and study groups for treatment. In the treatment stage; the control group animals were treated with tap water, while the study group animals were received Süreyya I hot spring mineral water. Clinical, hematological, blood biochemical and histopathological examinations was performed in all the animals before study, after myocardial infarction, and on 1st, 7th, 14th and 21st days after treatment. In terms of T, P and R, there were significant differences (p <0.05) with respect to time periods between control and study groups (p <0.05). WBC, NOTR, MON MCH, HCT ve MCV levels decreased, while RBC, HG, HCT, LENF, MCH and MCHC levels increased following treatmen in both groups. These changes were significant in study group comaper to control. It was also seen that ALT, AST, CK and CRP levels of blood biochemical parameters were significantly increased (p <0.05) after myocardial infarction formation. By begining treatment, TP, ALB and GLU levels increased, whereas ALT, AST, CK and CRP levels decreased, especially on the 21st day of the study in the SG. It was concluded that in the correct temperature and time to use Süreyya I hot spring water as drinking and bathing was very successful in the treatment of myocardial infarction, either itself or along with other medical treatments.