Abstract
The aim of this study was to determine the efficacy of Afyokarahisar termomineral water in the treatment of nephritis. For this purpose, 40 Albino mouse at the same daily age were used. Nephritis was induced by adding adenine to their feed at a rate of 0.2% for 6 weeks. After nephritis was induced, a 21-day treatment period was started, and the mice were equally divided into two groups as control and study. While control group mice were received tap water daily and bathing in tap water, study group animals were given fresh Süreyya I hot spring water daily and bathing in this water. Clinical, hematological, blood biochemical and histopathological examinations were performed before the study, after nephritis formation, and on days of 1st, 7th, 14th and 21st of treatment period. Results of this study showed that WBC, NEUT and MCV levels increased significantly (p < 0.05) following nephritis formation, while RBC, HB, HCT, LYM, MCH and MCHC levels decreased significantly (p < 0.05). It was also determined that AST, GGT, GLU, BUN and IgG levels of blood biochemical parameters were significantly increased (p < 0.05) and TP, ALB levels decreased significantly (p < 0.05) after nephritis formation. At the end of the study, it was seen that all the measured parameters turned to the normal range in the study group animals, whereas problems still continuing with control group animals. Consequently, it was concluded that Süreyya I hot spring water was very successful in the treatment of nephritis and considered as an option in the treatment of nephritis.
Highlights
For citation: Elitok Bülent, Yasin Agilonu, Ulusoy Yavuz, Kilinç Bahadir
SUMMARY The aim of this study was to determine the efficacy of Afyokarahisar termomineral water in the treatment of nephritis
Hematological, blood biochemical and histopathological examinations were performed before the study, after nephritis formation, and on days of 1st, 7th, 14th and 21st of treatment period
Summary
Практическая часть данного исследования была проведена в Центре прикладных и экспериментальных исследований животных Университета Афьон Коджатепе в соответствии с инструкциями Комитета по этике Университета экспериментальных исследований животных Афьон Коджатепе (AKUHADYEK) согласно отчету под номером 59-18 и была утверждена в качестве магистерской диссертации Комитетом по научно-исследовательским проектам Университета Афьон Коджатепе (AKÜBAPK), номер проекта 18.SAĞ.BİL.. До начала эксперимента у 4 из 40 лабораторных животных взяли образцы крови. После развития нефрита у 4 из 36 мышей взяли пробы крови, а также образцы тканей для гистопатологических исследований. Животных этой группы в течение всего срока исследования в одно и то же время по одному разу каждый день купали по 15 мин в водопроводной воде, температура которой составляла (35 ± 2) °С. Мышей экспериментальной группы поили свежей термальной водой, к которой был обеспечен ежедневный доступ. Животных ежедневно в одно и то же время в течение 15 мин купали в свежей термальной воде, температура которой составляла (35 ± 2) °С. Отбор проб крови и ткани почек осуществляли под анестезией с использованием кетамина (100 мг/кг) и ксилазина (10 мг/кг) [10] до начала исследования, после развития нефрита и на 1, 7, 14 и 21-е сут после начала эксперимента. Данные были выражены как среднее значение ± стандартная ошибка и считались значимыми при p < 0,05
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