Abstract
Diabetes mellitus type 2 is the world's most common chronic metabolic disease it’s characterized by an increased level of blood glucose without changes in insulin liberation in the first stage. The goal of this study was to see the relationship between glutathione peroxide (GPX) activity, butyrylcholinesterase (BuchE) concentration, fasting blood glucose (FBG), and Lipoic acid synthetase (LIAS) concentration in sera of type 2 diabetes patients, and as biomarkers for illness progression monitoring and prediction. ELISA kits were used to assess all biomarkers in this study. In this study, FBG and HbA1c levels in patients are significantly higher (P > 0.05) than in the control group. The activity levels of Gpx were lower in diabetic patients (46.5 ±11.81U/ml) than in healthy controls (59.72 ±17.2 U/ml) (p<0.001). The Concentration of Butyrylcholinesterase (BuChE) in control was 13.127(14.158-12.219) pg/ml whereas, its Concentration in patients group significantly increased (p<0.001) to 15.787(14.278-17.657) pg/ml. whereas lipoic acid synthetase (LIAS) concentration in the control was insignificantly increased to 11.66(13.38-10.19) pg/ml than in patients 8.77(6.57-10.04) pg/ml (P= 0.824).
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