Abstract
The development of new molecular probes targeting receptors with high specificity in selected cells and tissues highlights the importance of obtaining the anatomical context in Positron Emission Tomography (PET) imaging. This can be achieved using another imaging modality, such as X-ray Computed Tomography (CT) or Magnetic Resonance Imaging (MRI), but the anatomic and molecular images obtained sequentially with different scanners must subsequently be co-registered and are subjected to motion artifacts. Conventional CT imaging also contributes a significant dose, which may compromise the benefits of longitudinal molecular imaging studies in the same subject. To overcome these difficulties, we have investigated the use of the LabPET™ detector and electronics as a multi-modal detection system. Based on fast light emitting inorganic scintillators individually coupled to avalanche photodiodes and parallel, low-noise, fast digital processing electronics, the proposed detector front-end is suitable for coincidence detection of annihilation radiation (511 keV) in PET and for ultra-fast low-energy X-ray photon counting in CT. This combined detection system enables concurrent PET/CT imaging while potentially achieving superior image contrast sensitivity for a given dose in CT photon-counting mode. Anatomical images with millimeter spatial resolution and sufficient tissue contrast for anatomical localization in small animals have been obtained with doses in the mGy range. The CT performance for dual-modality imaging of small animals was analyzed in terms of spatial resolution, noise and image contrast sensitivity as a function of dose.
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