Abstract
The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on drug release were studied and compared to those obtained with a reference formulation prepared with HEC. It was shown that the use of HPMC in the gel formulation contributes to the improvement of drug release and consequently its biodisponibility. Indeed, the increase in HPMC concentration forms a controlled system release because polymer chains relaxation. The drug is released under the effects of two phenomena: diffusion and relaxation of polymeric chains. Thus, the kinetic release passes from the kinetics of case II towards Fickian diffusion.
Highlights
Gels are semisolid networks containing two interpenetrating phases, a gelling agent and liquid
The objective of this work was the evaluation of the effects of the nature and concentration of cellulose derivatives on the drug release kinetics
3.1 Preliminary experiments A reference gel based on hydroxyethyl cellulose (HEC) was characterized in terms of sustained release of drug
Summary
Gels are semisolid networks containing two interpenetrating phases, a gelling agent and liquid. When the liquid is water, these systems are called hydrogels. Hydrogels have the particularity to absorb and release water solutions in a reversible manner (Robinson et al, 1993). Among the polymers used to form hydrogels, polysaccharides of natural Journal of Pharmaceutical. Technology, Research and origin have interesting and original properties in comparison with synthetic. Management polymers (Manjanna et al, 2010). Vol 1 used in many pharmaceutical formulations (Bajpai et al, 2008). Their use as matrices in the formulation of hydrogels has received an increasing attention
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