Abstract
Kutajarishta (KTJ) is an Ayurvedic formulation approved by the National formulary of Ayurvedic Medicine 2011, of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. Our present studies make an attempt toward identifying probable anti-nociceptive and anti-inflammatory mechanisms of KTJ. KTJ, at three doses, (10mL/kg, 20mL/kg, and 40mL/kg) showed no involvement of the CNS in anti-nociceptive activity of KTJ. Carrageenan induced paw edema and acetic acid writhing tests both gave significant results (P ? 0.05), indicating possible peripheral analgesic and anti-inflammatory action. Formalin induced paw-licking test showed that KTJ had significant effect in suppressing inflammatory pain (P?0.05) but not neurogenic pain. Hence our study shows anti-inflammatory and peripheral analgesic action for KTJ.
Highlights
World health Organization (WHO) has stated that up to 80% of the population in many Asian and African countries depend on traditional and complimentary drugs to meet their medical necessities 1
We analyzed the analgesic and anti-inflammatory property of Kutajarishta (KTJ), a commonly available herbal product licensed under the Directorate General of Drug Administration (DGDA) of Bangladesh
For Acetic acid induced writhing test and Formalin test, Statistical significance was determined by One-way Analysis of Variance (ANOVA) followed by post hoc Dunnett test
Summary
World health Organization (WHO) has stated that up to 80% of the population in many Asian and African countries depend on traditional and complimentary drugs to meet their medical necessities 1. Persistent continuation of a regimen with one of these drugs which do not have any pharmacological activity, in reality, would seriously aggravate the morbidity of the patients For these reasons and others, there has been a demand for ensuring the safety and efficacy of some of these traditional/herbal medicines[2]. Pain has been defined by The International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage[4]. Kutajarishta (KTJ) is included in the Bangladesh National Formulary of Ayurvedic Medicine 2011 (2nd Ed.)[7] It is primarily indicated in rheumatoid arthritis, lumbago (low-back pain) and sciatica (pain which may arise from compression and/or irritation of one of five spinal nerve roots which give rise to each sciatic nerve)[7]. All other reagents were procured from Sigma Aldrich (USA) unless mentioned otherwise
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