Abstract
A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several degree based upon EDSS scale. Ultrasound osteometry of the calcaneus, computer tomography of QCT of L1—L3 vertebras were performed, serum crosslaps, N-MID osteocalcin were used. Decreased bone density, injured bone microarchitectonics and suppression of bone formation and resorption, which were correlated EDSS were found. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed. This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity.
Highlights
Ряд исследований свидетельствуют об актуальности проблемы остеопенического синдрома при рассеянном склерозе, однако еди ное мнение о факторах, приводящих к его развитию, отсутствует
A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development
We observed 65 patients with multiple sclerosis with various type of its course and disability sta tus of several degree based upon EDSS scale
Summary
Ряд исследований свидетельствуют об актуальности проблемы остеопенического синдрома при рассеянном склерозе, однако еди ное мнение о факторах, приводящих к его развитию, отсутствует. Предпринято обсервационное обследование 65 больных рассеянным склерозом с различным типом течения и степенью инвалидизации по шкале EDSS. Это позволило сделать вывод о том, что основная причина снижения массы кости у больных рассеянным склерозом — резкое снижение фи зической активности. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity. В связи с вышесказанным целью настоящего исследо вания явилось уточнение факторов развития остеопениче ского синдрома и его патогенетических особенностей у больных рассеянным склерозом
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