Abstract
AbstractBackground & objectives: In the present study, to evaluate oxidative stress in type 1 diabetes mellitus (IDDM), serum, leukocyte and erythrocyte lipid peroxidation and and erythrocyte and leukocyte glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities, and serum and leukocyte vitamin C levels of patients and healthy controls were investigated in order to determine the effect of free radicals in these patients. Lipid peroxidation was measured in terms of malondialdehyde which is an end product of peroxidation.Methods: Patients consisted of 34 cases (20 female,14 male) aged 3-27 years and controls consisted of 29 subjects (13 female, 16 male) aged 3-18 years.Results: There was at least, a tentency toward an increase in lipid peroxidation and a decrease in antioxidant systems in children and adolescents with IDDM which is corrected by insülin treatment. Additionally, there was no correlation between the above parameters and HbA1c and glucose levels.Conclusions: These disturbances were concluded to be due to some other factors rather then diabetes itself.
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