Abstract
Objective The epidemiological characteristics and the laboratory testing results of the rubella outbreaks in Tang county were investigated to provide basis for the control measures of rubella epidemics. Methods All possible cases were studied by epidemiological case investigation. The serum specimens were collected and IgM against rubella virus was detected by enzyme-linked immunosorbent assay (ELISA). The viral nucleic acid in throat swab specimens was analyzed by fluorescent quantitative PCR. The target nucleic acid sequences were used for genotyping and phylogenetic analysis. Results Fifteen rubella outbreaks occurred in Tang county. The cases distributed in 15 primary and secondary schools. Among them, 61.0% of cases had no history of rubella vaccination. One hundred and five cases were confirmed by laboratory and 18 strains of rubella virus were isolated. The strains all belonged to genotype 2B. Conclusions Enhancement of epidemiological and laboratory monitoring, active control measures of rubella epidemics and vaccination for unimmunized individuals were necessary measures for the prevention and control of rubella outbreaks.. Key words: Primary and secondary school; Rubella virus; Outbreak; Genotype
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