Investigation of relation between mortality of geriatric patients with sepsis and C-Reactive Protein, Procalcitonin and Neutrophil/Lymphocyte ratio in admission to intensive care unit

Abstract

Introduction: Sepsis is defined as life-threatening organ dysfunction caused by the body's irregular response to infection. Sepsis is the most common cause of death in intensive care units in elderly patients. The effect of CRP, procalcitonin levels and neutrophil/lymphocyte ratio at the time of admission on mortality of internal diseases patients in ICU over 65 years of age are investigated in this study.Methods: The medical records of 207 patients with sepsis hospitalized between June 2018 and May 2019 in the Internal Medicine ICU of Bozyaka Training and Research Hospital were evaluated retrospectively in this cross-sectional study. Demographic data, APACHE II score, SOFA score, presence of systemic disease, CRP, procalcitonin, complete blood count, ICU stay and mortality status were recorded.Results: The mean age of the geriatric patients with 207 sepsis hospitalized in the ICU over a 12-month period was 77.6±8.4 years. The study group consisted of 100 (48.3%) males and 107 (51.7%) females. In the study, 73(35.3%) of the patients died due to sepsis, 134(64.7%) were the surviving group. There was no difference between surviving and deceased patient groups in terms of length of stay (p=0.880). APACHE-II and SOFA scores were found to be statistically different between surviving and deceased patients (p<0.001). The mean procalcitonin level was 3.54±4.77µg/L among the surviving group and 20.83±12.18µg/L among the deceased patient group (p<0.001). The mean CRP was 97.7±77.4mg/L by the surviving group and 136.9±100.8 mg/L by the deceased patient group (p=0.002). The neutrophil/lymphocyte ratio was 7.49±6.83 in the surviving group and 12.73±15.09 in the deceased patient group (p=0.006).Conclusion: Mortality rates of inpatients in ICU were higher than inpatients in other wards. Systematic evaluation of neutrophil/lymphocyte ratio, CRP and procalcitonin results, as well as complete blood count parameters during hospitalization, may be valuable in predicting intensive care outcomes of patients.