Investigation of Propagating Cortical Waves and Spirals Recorded by High Density Porous Graphene Arrays.

Abstract

Propagating waves along the cortical surface have recently attracted significant attention by the neuroscience community. However, whether these propagating waves imply network connectivity changes for the neural circuits is not known. In this work, we employ a high density porous graphene microelectrode array and perform in vivo experiments with rodents to investigate network connectivity during cortical propagating waves. The spatial-temporal analysis of the cortical recordings reveals various types of propagating waves across the recording area. Network analysis results show that these propagating waves are consistent with the functional connectivity changes in the neural circuits, suggesting that the underlying network states are reflected by the cortical potential propagation patterns.