Abstract
Pneumocystisjirovecii (P. jirovecii) is an opportunistic pathogeninhumans.Early diagnosis and optimal treatment of patients with P. jirovecii pneumonia (PJP) remains a key priority.This study investigated P. jirovecii in patients with lung cancer using the nested-polymerase chain reaction (PCR) method and examined the relationship between P. jirovecii and clinical findings. The study included 60 patients with lung cancer and 30 patients without lung cancer.The bronchoalveolar lavage (BAL) fluid samples of these 90 individuals were taken for diagnostic purposes in the University of Health Sciences Turkey, Van Training and Research Hospital, Clinic of Chest Diseases.Patient information was recorded.After DNA isolation from the BAL fluid samples taken from patients, the nested-PCR protocol for amplification of mtLSUrRNA in P. jirovecii was performed. P. jirovecii DNA was detected in 40 (66.67%) of the lung cancer patients included in the study and in six (20%) patients without lung cancer, that is, in46(51.11%) patients. The rate of nested-PCR positivity in the lung cancer group was significantly higher thanthat inthe non-lung cancer group (p=0.0001).Additionally,a statistically significant correlation was found between anorexia and weight loss, fever and sputum P. jirovecii positivity in patients with lung cancer (p<0.005). Thesefindingssuggestthat lung cancer patients should be evaluated for PJP.
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