Abstract
In recent times, terahertz (THz) technologies have been actively applied in many biomedical research work, including gastric cancer diagnosis. In order to provide an effective removal of tumor during surgery, it is necessary to clearly distinguish it from different membranes of the stomach. In this work, we reported an investigation of various normal and cancer fresh gastric tissues using terahertz time-domain spectroscopy in the reflection mode. Refractive index and absorption coefficient of moderately differentiated and poorly differentiated gastric adenocarcinomas, as well as both serosa and mucosa were obtained in the frequency range from 0.2 to 1 THz. All cancer tissues were distinguishable from normal ones. The influence of the morphology of the investigated tissues on the obtained optical properties is discussed. The obtained results demonstrated a potential of THz time-domain spectroscopy to discriminate a tumor from normal serous and mucous gastric membranes. Thus, this method might be applied to gastric cancer diagnosis.
Highlights
Gastric cancer is one of the leading causes in terms of mortality and the number of diseases throughout the world
Normal and cancer fresh gastric tissues under this study were obtained from 4 patients with poorly and moderately gastric adenocarcinoma after gastrectomy, in the Pavlov First St
Normal and cancer fresh gastric tissues under this study were obtained from 4 patients with structure—the tumor tissue grown from the mucosa occupied one side, and a tumor that invaded into poorly and moderately gastric adenocarcinoma after gastrectomy, in the Pavlov First St
Summary
Gastric cancer is one of the leading causes in terms of mortality and the number of diseases throughout the world. It is estimated that in 2018 more than 1,000,000 diseases of the stomach cancer were diagnosed, and the number of deaths reached 783,000 [1]. Gastric cancer can be removed by the endoscopic resection method or surgical operation. The first one is more painless and safe for the patient, it can only be used at the early stages of cancer and after timely endoscopic diagnosis [2]. During surgery treatment it is important to discriminate between cancer regions and delineate the boundaries between tumor and normal tissue. Accurate intraoperative diagnosis of cancer improves the efficiency of cancer resection and can save more healthy tissues as well as increase the survival of patients after surgery
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