Investigation of flurbiprofen axetil on analgesic efficacy in nerve-injured rats

Abstract

Objective To investigate the influence of different doses of flurbiprofen axetil on neurological behavior in CCI rats. Methods All SD rats were randomly assigned to 3 groups: control group(C group), operation but without CCI, n=5; CCI group, without injection, n=5; flurbiprofen axetil (FA) group, different doses of flurbiprofen axetil were intraperitoneally administered every 12 hours for 7 days beginning on postoperative 6 hours in CCI rats (FA1 group: 2mg/kg, FA2 group: 4mg/kg, FA3 group: 8mg/kg, FA4 group: 16mg/kg ), 5 rats in each subgroup.The thermal withdrawal latency(TWL) and mechanical withdrawal threshold(MWT) were tested on preoperative 1, 3, 5 and 7 days and postoperative 1, 3, 5 and 7 days. Results Firstly, compared with C group[TWL: (12.396±1.144)s; MWT: (12.801±0.494)g], the TWL and MWT of CCI and FA groups[TWL: (5.645±1.144)s, (5.901±0.914)s, (6.300±0.835)s, (7.631±0.597)s, (7.894±0.526)s; MWT: (5.14±0.71)g, (5.28±0.60)g, (6.74±0.50)g, (6.74±0.25)g, (6.70±0.42)g]were significantly declined after surgery (tTWL=26.973, 31.047, 31.176, 30.373, 30.772; tMWT=44.192, 48.132, 51.136, 54.326, 46.937, all P 0.05). However, the TWL and MWT of FA2 group, FA3 group and FA4 group[TWL: (6.300±0.835)s, (7.631±0.597)s, (7.894±0.526)s; MWT: (6.74±0.50)g, (6.74±0.25)g, (6.70±0.42)g] increased significantly compared with CCI group(tTWL=-3.768, -11.569, -13.867, tMWT=-3.898, -15.233, -14.801, all P 0.05). Conclusion Over 4mg/kg of flurbiprofen axetil can significantly reduce the thermal hyperalgesia and mechanical allodynia in CCI rats, however, there is a ceiling effect of flurbiprofen axetil, and the dosage of 8mg/kg can provide a maximum analgesic effect. Key words: Neuralgia; Flurbiprofen axetil