Investigation of Electrochemical Oxidation Mechanism, Thermodynamic Parameters and Sensor Design for Analgesic and Relaxant Drug: Phenyramidol in Aqueous Medium by NH2fMWCNT

Abstract

In this study, the electrochemical oxidation mechanism of phenyramidol HCl (PhA) was investigated in aqueous medium. An amine functionalized multi walled carbon nanotube (NH2fMWCNT) modified glassy carbon electrode (GCE) was used as a sensitive and fast sensor for the determination of PhA. Scanning electron microscopy (SEM) with Energy Dispersive X-Ray (EDX), analysis and electrochemical impedance spectroscopy (EIS) were applied for investigation of surface morphology. Cyclic voltammetry (CV) differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV) methods were employed to compare the redox responses of PhA on the surface of bare and modified electrode with NH2fMWCNTs. The results showed a considerable enhancement in the peak current of PhA with AdSDPV. A linear calibration curve was obtained in the concentration ranges of 0.8–100 μM, with a detection limit of 6.13 × 10−8 M and 2.78 × 10−8 M from peaks 1 and 2, respectively. The proposed procedure was easily and sensitively applied for the determination of PhA in human serum samples and tablet dosage form with satisfactory recovery value (recovery >99%).