Abstract
Edaravone (EDA) is an effective antioxidant that is easily degraded, which diminishes its therapeutic efficiency. The present study assessed the hydrolytic and oxidative degradation of edaravone and its solid dispersion with Kollidon VA 64, a water-soluble polymer. The characterization of the edaravone and solid dispersion was done by Fourier Transform Infrared Spectroscopy, X-ray diffraction, and Differential Scanning Calorimetry. The results revealed that edaravone undergoes extensive degradation under hydrolytic conditions at pH 2, 5, 7, 10 with the following respective rate constant K: 0.00983 through 0.0107, 0.01279, and up to 0.0201 min⁻¹, as well as under oxidative conditions in 3% H₂O₂ with a K of 0.00924 min⁻¹. The stability of solid dispersion with KVA 64 was greater with a reduced degradation rate constant of 0.00326, 0.00109, 0.00145, 0.00277 min⁻¹ in pH 2, 5, 7, 10, respectively, and under oxidative conditions in 3% H₂O₂ with a rate constant K 0.00392 min⁻¹. The study provides valuable insights into the degradation kinetics and stabilization of edaravone using solid dispersion.
Published Version
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