Abstract
This study investigates some effective parameters in betamethasone release from in situ forming biodegradable drug delivery systems. The drug delivery systems are based on two biodegradable polymers of poly(D,L-lactide-co-glycolide) (PLGA), which are commercially called RG504h and RG756. Temperature, polymer type, and γ-irradiation are the parameters investigated by attenuated total reflectance Fourier transform-infrared (ATR-FTIR) spectrometry in the 1891–1324 cm−1 spectral region. Obtained results were compared with those of the HPLC method, demonstrating several similarities. N-methyl-2-pyrrolidinone (NMP) was employed as solvent. The γ-radiation (25 kGy) has no effect on decomposition of betamethasone, while it increases the rate of drug release. RG756 reduces the release rate in comparison with RG504H. Temperature does not affect the amount of free drug in the polymer matrix. The partial least squares (PLS) regression method with path length constant, mean centering, and variance scaling techniques was applied. Correlation coefficient R2 and root mean square error of calibration (RMSEC) were 0.998 and 0.106 respectively.
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