Abstract
ABSTRACTWe demonstrate a versatile class of nanoscale sensors based on single-stranded DNA (ss-DNA) as the chemical recognition site and single-walled carbon nanotube field effect transistors (swCN-FETs) as the electronic readout component. Coating swCN-FETs with ss-DNA causes a current change when exposed to gaseous analytes, whereas bare swCN-FETs show no detectable change. The responses differ in sign and magnitude depending both on the type of gaseous analyte and the sequence of DNA. Our results suggest that the conformation of ss-DNA on swCN-FET plays a role in determining the sensor response to gaseous analytes. The conformation depends not only on the base content of the oligomer, but also on the specific arrangement of the bases in the ss-DNA. We compare our results with the molecular dynamic simulations for understanding of the sensing mechanisms. SsDNA/swCN-FETs possess rapid recovery and self-regenerating ability, which could lead to realization of large arrays for sensitive electronic olfaction and disease diagnosis.
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