Investigation of Different Components of Parallel-Hole Collimator Response to Different Radioisotope Energies Used in Nuclear Medicine Imaging.

Abstract

The quality of images obtained from the nuclear medicine imaging systems depends on different factors. One of the most important of these factors is the geometrical and physical characteristics of collimator used for imaging with a given radioisotope. The aim of this study is to investigate the contribution of different components of collimator response for determining the most suitable parallel-hole collimator for the different radioisotope energies used in nuclear medicine imaging. In this study, the SIMIND Monte Carlo simulation program is used to determine the contribution of geometrical, penetrating and scattered response components of four hexagonal parallel-hole collimators including low-energy high-resolution (LEHR), low-energy general-purpose (LEGP), medium-energy general-purpose (MEGP), and high-energy general-purpose (HEGP) collimators, for 12 different energies used in nuclear medicine imaging. According to the simulation results, the use of both the LEHR and LEGP collimators leads to a geometrical component above 60% for energies between 69 and 171 keV. On the other hand, for energies between 185 and 245 keV, the MEGP collimator and for energy of 364 keV, the HEGP collimator gives the geometrical components above 70% and 60%, respectively, while for energy of 511 keV, the geometrical response of all four collimators is below 20%. The results of this study show that for two low-energy single-photopeak radioisotopes, Tc-99m and I-123, the LEHR and LEGP collimators, and for high-energy single-photopeak radioisotope, I-131, the HEGP collimator are most suitable collimators. For dual-photopeak In-111 radioisotope and triple-photopeak Ga-67 radioisotope, the MEGP and HEGP collimators and for triple-photopeak Tl-201 radioisotopes, the LEHR and LEGP collimators are proposed as most suitable collimators.