Abstract
Aim:This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp.Materials & methods:The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis.Results & conclusion:Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.
Highlights
The Copaifera langsdorffii, Copaifera duckei, Citrus reticulata, Copaifera multijuga and Copaifera trapezifolia oleoresins were effective against the Mycobacterium spp evaluated in this study. Among the investigated Copaifera species, C. duckei displayed the best antimycobacterial results. Oleoresins in the absence of isoniazid were more effective
It is necessary to understand their mechanism of action and to undertake further studies on molecules obtained from Copaifera spp. oleoresins
Summary
This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. Lay abstract: The purpose of this paper was to evaluate the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. against a panel of bacteria capable of causing tuberculosis. Considering the pharmacological potentials of Brazilian Copaifera species [39], this study aimed to evaluate the antimycobacterial activity of the oleoresins and hydroalcoholic crude extracts obtained from Copaifera spp. leaves against some mycobacterial species and the interaction between compounds from this plant species and the antibiotic isoniazid
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