Abstract
Objective To study the change of cerebrospinal fluid (CSF) and plasma interleukin-6 (IL-6) levels in neonatal hypoxic-ischemic encephalopathy (HIE) , and explore the relationship between IL-6 levels and severity of brain damage. Methods IL-6 in CSF and plasma were measured in 24 neonates with HIE and 8normal term neonates by enzyme-linked immunosorbent assay. Results CSF IL-6 level was much higher in acute stage of severe HIE with brain damage as compared with the control group and moderade, mild form of HIE. There were no significant differences between the four groups in plasmaIL-6 levels. Conclusion The changes of CSF IL-6 level in neonates with HIE is related to the severity of HIE and brain damage. It is suggested that IL-6 might play a role in the pathogenesis of neonatal HIE. Key words: Cerebral anoxia; Cerebral ischemia; Infant, newborn; Interleukin-6
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