Investigation of biomarkers for coronary syndrome complications in patients with and without diabetes in Basra Province

Abstract

Myocardial infarction (MI) is the necrosis of myocardial tissue caused by a decrease in blood oxygen supply caused by a critical blockage of the coronary arteries by embolus or thrombus. MI with ST-segment elevation (STEMI) is associated with complete occlusive in the coronary artery resulting in the death of myocardial tissue, and is the worst form of ACS. This study aimed to compare the biochemical markers of myocardial infarction patients with and without ST elevation, which is an essential step for the proper management of patients. Based on the result, in STEMI complication patients with diabetes show a highly significant increase in AST, LDH, CK-MB and Troponin compared to NSTEMI patients. While patients without diabetes, show highly increase in AST and troponin compared to NSTEMI patients. In disease groups with (ACS) complication, in the case of STEMI, diabetes patients show a significant increase in all biomarkers except Vitamin D and Mg compared to the patients without diabetes. In the case of NSTEMI, diabetes patients show a significant increase in FBS, HbA1C, CK-MB, Troponin, urea, and creatinine compared to the patients without diabetes. The study showed a significant difference in biomarkers between patients having MI with and without diabetes according to forms of acute coronary syndrome STEMI compared to NSTEMI.