Abstract
Human myeloma is often used to depict primary myeloma cells since it does not completely capture patient variability. The majority of its genetic history is unclear. Fibroblast Growth Factor Receptor (FGFR) is one of four highly-conserved cell-membrane-related FGFR1-4 systems that are involved in embryo-growth, development, cell proliferation, and angiogenesis in the signaling processes. This study aimed to investigate FGFR3 polymorphisms using PCR-SSCP analysis in 40 patients and healthy persons as control for myeloma cancer. PCR approach was used for screening FGFR3, followed by single strand conformation polymorphism (SSCP), which show that the FGFR3 variations of the gene polymorphism might be affected by myeloma susceptibility. The results showed possibility to detect Multiplemyeloma by the variations of FGFR3 gene polymorphisms.
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