Abstract
The goal of this work is to investigate the peculiarities of biodistribution and the effects of gold nanoparticles in different organs and tissues of animals after intravenous administration. Nanoparticles are shown to produce neither acute nor long-term pathomorphologic alterations in the organs of healthy mice. Using transmission electron microscopy, a significant number of nanoparticles were detected in blood and urine 4 h after administration. Gold nanoparticles are shown to accumulate primarily in the spleen and kidneys, with a peak accumulation being reached on day 7 after injection. Single nanoparticles are detected in the brain, heart, and liver.
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